*Case definition:* For participants from all sites, XFS cases have clinical documentation of characteristic fibrillary material, either on the lens, pupillary ruff, anterior vitreous face, or anterior segment angle during slit biomicroscopic exam or through medical record review. Angle closure glaucoma will not be an exclusion criterion, as there is a higher risk of angle closure in patients with XFS. Our primary outcome of interest will be XFS; XFG will be considered an outcome of interest in secondary analyses. XFG will be defined by clinical evidence of both exfoliation material and glaucoma. Glaucoma status is the same definition we have used for the GLAUGEN, NEIGHBOR and NEIGHBORHOOD studies defined as: Level 1 (most likely affected with vCDR >0.7 in at least one eye, visual field defects consistent with the optic nerve examination and characteristic for glaucoma in at least one eye, and IOP >22mmHg in at least one eye); Level 2 (likely affected with 2 of three criteria listed above); Level 3 (possibly affected with one of the three criteria above) and Level 0 (no evidence of glaucoma using the criteria above). The vast majority of cases and controls are Caucasian, reflecting the populations used for this study and the fact that the disease is rarely observed in individuals of African race. Non-Caucasians identified by analysis of population substructure be analyzed separately.
Item
*Case definition:* For participants from all sites, XFS cases have clinical documentation of characteristic fibrillary material, either on the lens, pupillary ruff, anterior vitreous face, or anterior segment angle during slit biomicroscopic exam or through medical record review. Angle closure glaucoma will not be an exclusion criterion, as there is a higher risk of angle closure in patients with XFS. Our primary outcome of interest will be XFS; XFG will be considered an outcome of interest in secondary analyses. XFG will be defined by clinical evidence of both exfoliation material and glaucoma. Glaucoma status is the same definition we have used for the GLAUGEN, NEIGHBOR and NEIGHBORHOOD studies defined as: Level 1 (most likely affected with vCDR >0.7 in at least one eye, visual field defects consistent with the optic nerve examination and characteristic for glaucoma in at least one eye, and IOP >22mmHg in at least one eye); Level 2 (likely affected with 2 of three criteria listed above); Level 3 (possibly affected with one of the three criteria above) and Level 0 (no evidence of glaucoma using the criteria above). The vast majority of cases and controls are Caucasian, reflecting the populations used for this study and the fact that the disease is rarely observed in individuals of African race. Non-Caucasians identified by analysis of population substructure be analyzed separately.
boolean
C0085973 (UMLS CUI [1,1])
C1704788 (UMLS CUI [1,2])
C0206368 (UMLS CUI [1,3])
C1518451 (UMLS CUI [1,4])
C0599878 (UMLS CUI [1,5])
C0023317 (UMLS CUI [1,6])
C0034121 (UMLS CUI [1,7])
C0392911 (UMLS CUI [1,8])
C0348014 (UMLS CUI [1,9])
C0419360 (UMLS CUI [1,10])
C0730229 (UMLS CUI [1,11])
C3274646 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C3843761 (UMLS CUI [2,3])
C0017605 (UMLS CUI [2,4])
C0206368 (UMLS CUI [2,5])
C3274433 (UMLS CUI [3,1])
C0206368 (UMLS CUI [3,2])
C0683944 (UMLS CUI [3,3])
C5554846 (UMLS CUI [3,4])
C1302869 (UMLS CUI [3,5])
C0017601 (UMLS CUI [3,6])
C1704788 (UMLS CUI [3,7])
C3846158 (UMLS CUI [3,8])
C0456947 (UMLS CUI [4,1])
C0392760 (UMLS CUI [4,2])
C3846158 (UMLS CUI [4,3])
C0449788 (UMLS CUI [4,4])
C0015392 (UMLS CUI [4,5])
C3887875 (UMLS CUI [4,6])
C2228469 (UMLS CUI [4,7])
C0017601 (UMLS CUI [4,8])
C0234708 (UMLS CUI [4,9])
C0456948 (UMLS CUI [5,1])
C0392760 (UMLS CUI [5,2])
C0449788 (UMLS CUI [5,3])
C0456949 (UMLS CUI [6,1])
C0392760 (UMLS CUI [6,2])
C0449788 (UMLS CUI [6,3])
C0243161 (UMLS CUI [6,4])
C5570826 (UMLS CUI [7,1])
C0332125 (UMLS CUI [7,2])
C0243161 (UMLS CUI [7,3])
C0007457 (UMLS CUI [8,1])
C0558058 (UMLS CUI [8,2])
C1257890 (UMLS CUI [8,3])
C0522498 (UMLS CUI [8,4])
C0027567 (UMLS CUI [8,5])
C0443299 (UMLS CUI [8,6])
C0936012 (UMLS CUI [8,7])
*Exclusion criteria:* There are no exclusion criteria for exfoliation status. For glaucoma status, patients will be scored as unknown for glaucoma if they have any evidence of any other form of glaucoma, including pigmentary glaucoma or anterior segment dysgenesis. Individuals who have received chronic steroid therapy are also excluded from the analyses.
Item
*Exclusion criteria:* There are no exclusion criteria for exfoliation status. For glaucoma status, patients will be scored as unknown for glaucoma if they have any evidence of any other form of glaucoma, including pigmentary glaucoma or anterior segment dysgenesis. Individuals who have received chronic steroid therapy are also excluded from the analyses.
boolean
C1298908 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0206368 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0017601 (UMLS CUI [2,2])
C0449820 (UMLS CUI [2,3])
C0439673 (UMLS CUI [2,4])
C1552551 (UMLS CUI [2,5])
C3887511 (UMLS CUI [2,6])
C2881005 (UMLS CUI [2,7])
C1862839 (UMLS CUI [2,8])
C0087111 (UMLS CUI [3,1])
C0205191 (UMLS CUI [3,2])
C0149783 (UMLS CUI [3,3])
C2828389 (UMLS CUI [3,4])